Sun proteins and Dpy19l2 forming LINC-like links are critical for spermiogenesis
نویسندگان
چکیده
منابع مشابه
Sun proteins and Dpy19l2 forming LINC-like links are critical for spermiogenesis
We have read with a great interest the excellent article by Pasch et al. (2015) which describes the role of Sun4 in sperm head formation and fertility. The authors have used a Sun4 knockout (Sun4) mouse model to study the function of Sun4 in spermatogenesis. They observed that homozygous Sun4 males are infertile and present a globozoospermia-like phenotype. Further, they demonstrate that Sun4 i...
متن کاملLINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins
Linker of nucleoskeleton and cytoskeleton (LINC) complexes span the nuclear envelope and are composed of KASH and SUN proteins residing in the outer and inner nuclear membrane, respectively. LINC formation relies on direct binding of KASH and SUN in the perinuclear space. Thereby, molecular tethers are formed that can transmit forces for chromosome movements, nuclear migration, and anchorage. W...
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Recently it has been revealed that when approaching the glass-transition temperature, T(g), the dynamics of a liquid not only drastically slows down, but also becomes progressively more heterogeneous. From our simulations and experiments of six different glass-forming liquids, we find that the heterogeneous dynamics is a result of critical-like fluctuations of static structural order, contrary ...
متن کاملMammalian Sperm Head Formation Involves Different Polarization of Two Novel LINC Complexes
BACKGROUND LINC complexes are nuclear envelope bridging protein structures formed by interaction of SUN and KASH proteins. They physically connect the nucleus with the peripheral cytoskeleton and are critically involved in a variety of dynamic processes, such as nuclear anchorage, movement and positioning and meiotic chromosome dynamics. Moreover, they are shown to be essential for maintaining ...
متن کاملComparative testicular transcriptome of wild type and globozoospermic Dpy19l2 knock out mice
BACKGROUND Globozoospermia is a male infertility phenotype characterized by the presence in the ejaculate of near 100% acrosomeless round-headed spermatozoa with normal chromosomal content. Following intracytoplasmic sperm injection (ICSI) these spermatozoa give a poor fertilization rate and embryonic development. We showed previously that most patients have a 200 kb homozygous deletion, which ...
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ژورنال
عنوان ژورنال: Biology Open
سال: 2016
ISSN: 2046-6390
DOI: 10.1242/bio.016626